Basic Research in Stroke
The Stroke Program investigates stroke pathogenesis and outcomes using molecular, biochemical, cellular, model organism, and human tissue approaches. A federally-funded program seeks to understand the molecular mechanisms of cerebral small vessel disease, with a focus on the genetic disorder CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopthy). In addition, UM Stroke Program investigators are identifying roles of nuclear hormone receptors in neuronal injury, recovery, and adaptation using animal models. Several projects are underway that seek to define physiological regulation of heart rate, sleep, biological rhythms, and brain electrophysiology in response to stroke.
Michael Wang’s lab is investigating the pathology and molecular mechanisms of CADASIL, the most common inherited cause of stroke and vascular dementia. Projects focus on proteins that play a role in protein accumulation in cerebral blood vessels and identification of changes in proteins that may be responsible for disease. This work is funded by the National Institutes of Health and the Department of Veterans Affairs.
Nuclear Hormone Receptors in Neurological Injuries
Nuclear hormone receptors modulate the outcomes in stroke and neuronal injury. In collaboration with Drs. Jimo Borjigin and Richard Mortensen, we are defining the mechanisms of how these receptors change the inflammatory system. Modulation of the inflammatory system may prevent injury of the brain in stroke and change the ability of the nervous system to spontaneously recover function after injury. Funding sources for this work include grants from the National Institutes of Health, the Department of Veterans Affairs, and the American Heart Association.
Effects of Stroke on Biological Rhythms, Sleep, and Cardiac Physiology
Stroke causes changes in circadian rhythms, sleep physiology, and heart rate variability. In collaboration with Dr. Jimo Borjigin, we are investigating the precise changes in the fundamental physiological processes and defining potential consequences of these disturbances. This work was funded by the Gilmore Fund for Sleep Research.