Clinical Research
Much clinical research is performed at the University of Michigan’s Comprehensive Stroke Center [link: http://www.uofmhealth.org/
Randomized Evaluation of Recurrent Stroke comparing PFO closure to Established Current Standard of Care Treatment (RESPECT)
The University of Michigan stroke program is a participating site in this randomized trial comparing PFO closure to best medical treatment for secondary prevention of stroke (funded by St. Jude Medical).
Site PI: Morgenstern.
CoreValve®
Dr. Zahuranec and Dr. Adelman are participating investigators in an ongoing series of trials investigating neurological and cardiac outcomes in patients Transcatheter aortic valve implant (TAVI). (Funded by Medtronic)
Cardiac MRI in Cryptogenic stroke
Dr. Zahuranec recently completed a pilot study comparing cardiac MRI to transesophageal echocardiogram for detection of embolic cryptogenic stroke. Funding: UM Cardiovascular Center McKay Grant.
Role of PCSK-9 inhibitors in stroke prevention
We are participating in a trial that looks at the role of a PCSK-9 inhibitor in prevention of stroke and vascular disease.
Funding: Amgen. Investigator: Adelman
Neurologic outcomes after transcatheter aortic valve replacement
We are evaluating neurologic outcomes after transcatheter aortic valve replacement.
Funding: Medtronic and UMHS CVC funding. Investigator: Adelman.
Stroke knowledge among inpatient nursing unit staff
Because 10% of strokes occur in hospitalized patients, we surveyed University of Michigan inpatient nurses to evaluate their knowledge of stroke symptoms.
PI: Adelman.
Phase 2B Study of TNK in Acute Stroke
This study compared standard dose IV rt-PA with IV TNK in the treatment of acute ischemic stroke within 3 hours of symptom onset.
Funding: NINDS. Site PI: Brown.
Genetics of Cerebral Hemorrhage with Anticoagulation (GOCHA)
This study is a case-control study assessing genetic risk factors for warfarin-related intracerebral hemorrhage.
Funding: NINDS. Site PI: Brown.