Clinical Research

Clinical Research

Much clinical research is performed at the University of Michigan’s Comprehensive Stroke Center [link:]. UM is a Regional Coordinating Stroke Center [link: ] for the NINDS StrokeNet [link:], and participates in clinical trials in acute treatment, stroke prevention, and recovery and rehabilitation through this network. Furthermore, investigators have developed their own projects on a variety of topics.

Randomized Evaluation of Recurrent Stroke comparing PFO closure to Established Current Standard of Care Treatment (RESPECT)

The University of Michigan stroke program is a participating site in this randomized trial comparing PFO closure to best medical treatment for secondary prevention of stroke (funded by St. Jude Medical).

Site PI: Morgenstern.


Dr. Zahuranec and Dr. Adelman are participating investigators in an ongoing series of trials investigating neurological and cardiac outcomes in patients Transcatheter aortic valve implant (TAVI). (Funded by Medtronic)

Cardiac MRI in Cryptogenic stroke

Dr. Zahuranec recently completed a pilot study comparing cardiac MRI to transesophageal echocardiogram for detection of embolic cryptogenic stroke. Funding: UM Cardiovascular Center McKay Grant.

Role of PCSK-9 inhibitors in stroke prevention

We are participating in a trial that looks at the role of a PCSK-9 inhibitor in prevention of stroke and vascular disease.

Funding: Amgen. Investigator: Adelman

Neurologic outcomes after transcatheter aortic valve replacement

We are evaluating neurologic outcomes after transcatheter aortic valve replacement.

Funding: Medtronic and UMHS CVC funding. Investigator: Adelman.

Stroke knowledge among inpatient nursing unit staff

Because 10% of strokes occur in hospitalized patients, we surveyed University of Michigan inpatient nurses to evaluate their knowledge of stroke symptoms.

PI: Adelman.

Phase 2B Study of TNK in Acute Stroke

This study compared standard dose IV rt-PA with IV TNK in the treatment of acute ischemic stroke within 3 hours of symptom onset.

Funding: NINDS. Site PI: Brown.

Genetics of Cerebral Hemorrhage with Anticoagulation (GOCHA)

This study is a case-control study assessing genetic risk factors for warfarin-related intracerebral hemorrhage.

Funding: NINDS. Site PI: Brown.